Currently I have a Bose L1 Model 2 with a B1 bass and a T8S mixer. My studio is approximately 250 sq ft, so take my input with a grain of salt. I’m hoping that this is a single data point that might be somewhat helpful.
I’m getting good clarity and volume in the studio with no feedback and have played gigs for up to 500 people with good results. (2 vocalists, bass, 2 electric/acoustic guitars and separate harmonizer channel). We’ve also played for ~150-person audiences outdoors. A couple of issues that might be worth considering : 1.) Electric guitars — my current band doesn’t feature any, but if we did, I’m not sure I’d be happy if I had to plug directly into a mixer, even for rehearsal (okay, I’m sure I wouldn’t be happy); 2.) Drums — I’m not certain whether you’ll really need to mic the drums in your studio. My former band was in a larger space than yours, and the drums were plenty loud without mics. Playing gigs, of course, is a whole different story. 3.) A single speaker column might not satisfy all of your bandmates, and locating it to give everyone what they want would likely be pretty tough
I’m hoping others will weigh in. There are lots of folks playing with multiple L1s with B2 bass modules, and that might be more appropriate for your needs.
I’m happy to answer any specific questions you might have.